منابع مشابه
Self-biotinylation of DNA G-quadruplexes via intrinsic peroxidase activity
The striking and ubiquitous in vitro affinity between hemin and DNA/RNA G-quadruplexes raises the intriguing possibility of its relevance to biology. To date, no satisfactory experimental framework has been reported for investigating such a possibility. Complexation by G-quadruplexes leads to activation of the bound hemin toward catalysis of 1- and 2-electron oxidative reactions, with phenolic ...
متن کاملEngineering of interlocked DNA G-quadruplexes as a robust scaffold
Interlock is a structural element in DNA G-quadruplexes that can be compared with the commonly used complementary binding of 'sticky ends' in DNA duplexes. G-quadruplex interlocking can be a basis for the assembly of higher-order structures. In this study, we formulated a rule to engineer (3 + 1) interlocked dimeric G-quadruplexes and established the folding topology of the designed DNA sequenc...
متن کاملRecognition and discrimination of DNA quadruplexes by acridine-peptide conjugates.
We have explored a series of trisubstituted acridine-peptide conjugates for their ability to recognize and discriminate between DNA quadruplexes derived from the human telomere, and the c-kit and N-ras proto-oncogenes. Quadruplex affinity was measured as the peptide sequences were varied, together with their substitution position on the acridine, and the identity of the C-terminus (acid or amid...
متن کاملInteractions of selected gold(III) complexes with DNA G quadruplexes.
The interactions of three representative gold(III) complexes with human telomeric DNA sequences were analysed using a variety of biophysical methods, including DNA melting, circular dichroism, SPR and ESI MS; remarkable interactions were highlighted for all tested complexes, although they were associated to significantly different binding profiles. The most interesting compound was Auoxo6, a di...
متن کاملA thermodynamic overview of naturally occurring intramolecular DNA quadruplexes
Loop length and its composition are important for the structural and functional versatility of quadruplexes. To date studies on the loops have mainly concerned model sequences compared with naturally occurring quadruplex sequences which have diverse loop lengths and compositions. Herein, we have characterized 36 quadruplex-forming sequences from the promoter regions of various proto-oncogenes u...
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ژورنال
عنوان ژورنال: Artificial DNA: PNA & XNA
سال: 2014
ISSN: 1949-095X,1949-0968
DOI: 10.4161/adna.28422